Fungal meningitis caused by Crypotococcus neoformans and usually occurs in severely immunosuppressed patients (e.g. advanced HIV, usually CD4 < 100).

  • It commonly presents with headache, fever, malaise developing over 1 or 2 weeks, progressing into confusion, photophobia, stiff neck
  • Diagnosis is through identification of the microorganism in the CSF with Indian Ink stain, antigen in CSF or culture