Organism causing neonatal septicemia are similar to the ones causing neonatal pneumonia and meningitis.


Supportive care

  • Keep baby warm
  • For high temperature, control environment i.e. (undress), avoid paracetamol
  • Prevent hypoglycaemia (breastfeeding if tolerated/possible, NGT or IV glucose)
  • Ensure hydration/nutrition
  • Give oxygen if needed (SpO2 < 90%)

First line treatment

  • Give ampicillin 50 mg/kg IV every 6 hours plus gentamicin 5 mg/kg every 24 hours for 10 days

If risk of staphylococcus infection (infected umbilicus or multiple skin pustules,

  • Give cloxacillin 50 mg/Kg IV/IM every 6 hours and gentamicin 5-7 mg/Kg every 24 hours
    • Clean infected umbilicus and pustules and apply gentian violet

If no improvement after 48-72 hours change from ampicillin to:

  • Ceftriaxone 100 mg/kg daily