TUBERCULOSIS PREVENTIVE THERAPY

Tuberculosis preventive therapy is recommended to prevent the development of active TB disease in an individual who
has latent TB infection (LTBI).

Uganda NTLP National preventive guidelines recommend preventive therapy using a six month regimen of Isoniazid
as monotherapy (Isoniazid preventive therapy, IPT) in the following cathegories: If

  • Persons living with HIV/AIDS
  • Child < 5 years, contacts of pulmonary TB patients

Do not use IPT in cases of active TB
Do not use IPT in contacts of MDR-TB

TREATMENT

  • Exclude active TB
    • Assess for cough, fever, weight loss and nights sweats (Children: cough, fever, poor weight gain)
    • If any of the TB symptoms are present, do clinical evaluation for TB
    • If none is present, TB is unlikely, then:
  • Give isoniazid for 6 months
    • Adults: 5 mg/kg/day (maximum 300 mg)
    • Children: 10 mg/kg/day (max. 300 mg per day)
  • Give Vitamin B6 (pyridoxine): 25 mg per day; given with isoniazid to prevent peripheral
    neuropathy

Note

  • HIV positive children < 1 year should receive IPT only if they have history of contact with TB case and active TB
    has been excluded