CARCINOMA OF THE ENDOMETRIUM

Is a probably the third commonest cancer in women in sub Saharan Africa after cervix and breast.

  • Main age is peri and post menopausal.
  • Associated with low parity, obesity, diabetes, and hypertension
  • May be preceded by endometrial hyperplasia due to unopposed oestrogen stimulation of endometrium.
  • Presents with abnormal uterine bleeding at the perimenopausal or post-menopausal period.

Clinical findings

  • May be unremarkable in early disease
  • Enlarged uterus
  • Evidence of metastasis may be evident in late cases.

Diagnosis

Histology of endometrial biopsy obtained through MVA, fractional curettage, or Novak or Kevorkian curets.

Treatment

  • By extended total abdominal hysteretomy (TAH)
  • Adjuvant chemotherapy and/or radiation may be needed in advanced cases.
  • High doses of progesterone are especially useful in advanced disease.

Management

Management is by a gynaecologist in conjunction with an oncologist.